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. Author manuscript; available in PMC: 2010 Dec 8.
Published in final edited form as: Cancer Cell. 2009 Dec 8;16(6):463–474. doi: 10.1016/j.ccr.2009.10.016

Figure 5. p85α mutants promote p110-dependent cell survival and Akt signaling.

Figure 5

(A-H) Stable expression p85α mutants alone (A, E), together with p110α (B, F) or p110β (C, G) or p110δ (D, H) promote IL3-independent survival of BaF3 cells (E-H) and elevated pAkt (A-D) levels. The cell survival effects (E-H) of p85α mutants are inhibited by a p110α/δ or p110β (TGX-221) inhibitor (Folkes et al., 2007; Jackson et al., 2005). Data shown in (E-H) are mean ± SEM of at least three independent experiments with multiple replicates. (*p<0.05 and **p<0.01)