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. Author manuscript; available in PMC: 2010 Dec 8.
Published in final edited form as: Cancer Cell. 2009 Dec 8;16(6):463–474. doi: 10.1016/j.ccr.2009.10.016

Figure 6. p85α mutants promote anchorage independent growth, p110 stabilization and proliferation.

Figure 6

(A-F) A representative image showing anchorage-independent growth (A-C) and number of colonies formed in the absence or presence of PI3K inhibitors (D-F) by BaF3 cells stably expressing p85α mutants together with p110α (A), p110β (B) or p110δ (C). (G, H) Pan-p85 null MEFs stably reconstituted with p85α mutants show stabilization of p110α̣ p110β and p110δ (G), elevated pAkt (G) and increased cell proliferation (H). Data shown (D-F, H) are mean ± SEM. (*p<0.05 and **p<0.01).