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. Author manuscript; available in PMC: 2010 Sep 1.
Published in final edited form as: J Endocrinol. 2009 Apr 14;202(3):327–336. doi: 10.1677/JOE-09-0041

Figure 2.

Figure 2

The three possible regulatory functions of 14-3-3 in the testis. (A) Effects on intracellular trafficking. 14-3-3 binding modulates endoplasmic reticulum (ER) transportation by masking the COPII (or COPI) binding sites on cargo proteins. (B) Effects on cell-junction dynamics. 14-3-3 participates in the integrin-activated signaling pathways via p130Cas. (C) Effects on cell polarity. Par1 catalyzes the phosphorylation of Par3, leading to 14-3-3 binding that inhibits the formation of Par3/Par6/aPKC complex. In turn, Par1 can be phosphorylated by aPKC (atypical protein kinase C) and bound with 14-3-3 as inactive form.