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. Author manuscript; available in PMC: 2010 Sep 1.
Published in final edited form as: J Endocrinol. 2009 Apr 14;202(3):327–336. doi: 10.1677/JOE-09-0041

Figure 3.

Figure 3

A hypothetical model illustrating the possible regulatory role of 14-3-3 during BTB restructuring at stage VIII of the seminiferous epithelial cycle of spermatogenesis. The direct contact between the Par3/Par6/aPKC complex and JAM-A stabilizes the BTB, conferring an intact barrier. At stage VIII of the epithelial cycle, the degradation or endocytosis of JAM-A (dashed line) induces the opening of BTB. This diminishing level of JAM-A at the BTB may be contributed by the disassembly of the Par3/Par6/aPKC protein complex, because of the masking of Par3 and/or Par6 by 14-3-3 protein.