Table 2.
Binding partner categories | Reported binding partners |
---|---|
Polarity proteins | Par1/MARK kinase protein families (Brajenovic et al. 2004, Jin et al. 2004, Goransson et al. 2006) Par3/Par6/aPKC complex (Brajenovic et al. 2004, Jin et al. 2004) |
Cell-junction proteins | p120 catenin (Jin et al. 2004) Plakophilin (Jin et al. 2004) AF6/afadin (Jin et al. 2004) |
Cytoskeleton | Actin and tubulin (Jin et al. 2004, Meek et al. 2004) |
Cytoskeleton-regulating proteins | Kinesin and profilin (Jin et al. 2004, Meek et al. 2004) |
Signaling proteins | PI-3 kinase (Meek et al. 2004) p130Cas (Garcia-Guzman et al. 1999) Raf kinase (Berruti 2000) |
ER localization | COP1 and COP2 (Shikano et al. 2006) |
This table is not intended to be exhaustive since more than a hundred binding partners for 14-3-3 have been identified in different epithelia (Jin et al. 2004, Meek et al. 2004) based on studies using gene-profiling techniques, among others. Only selected binding partners are listed here which are known to regulate spermatogenesis based on recent studies in the field.