Table 2.
Different classes of binding partners of 14-3-3 illustrating its potential role in regulating various cellular functionsa
| Binding partner categories | Reported binding partners |
|---|---|
| Polarity proteins | Par1/MARK kinase protein families (Brajenovic et al. 2004, Jin et al. 2004, Goransson et al. 2006) Par3/Par6/aPKC complex (Brajenovic et al. 2004, Jin et al. 2004) |
| Cell-junction proteins | p120 catenin (Jin et al. 2004) Plakophilin (Jin et al. 2004) AF6/afadin (Jin et al. 2004) |
| Cytoskeleton | Actin and tubulin (Jin et al. 2004, Meek et al. 2004) |
| Cytoskeleton-regulating proteins | Kinesin and profilin (Jin et al. 2004, Meek et al. 2004) |
| Signaling proteins | PI-3 kinase (Meek et al. 2004) p130Cas (Garcia-Guzman et al. 1999) Raf kinase (Berruti 2000) |
| ER localization | COP1 and COP2 (Shikano et al. 2006) |
a
This table is not intended to be exhaustive since more than a hundred binding partners for 14-3-3 have been identified in different epithelia (Jin et al. 2004, Meek et al. 2004) based on studies using gene-profiling techniques, among others. Only selected binding partners are listed here which are known to regulate spermatogenesis based on recent studies in the field.