TABLE 5.

RISK OF DEVELOPING CHRONIC GVHD WITHIN 1 YEAR AS A FUNCTION OF PULMONARY FUNCTION PARAMETERS

PFT parameter	N	Unadjusted HR (95% CI)	P-value	Adjusted HR* (95% CI)	P-value
LFS category	1373
0	619	Referent		Referent
1	621	1.04 (0.88 – 1.24)	0.623	1.01 (0.84 – 1.22)	0.902
2	123	1.38 (1.02 – 1.86)	0.035	1.40 (1.00 – 1.95)	0.048
3	10	2.93 (1.00 – 8.55)	0.049	3.11 (1.09 – 8.89)	0.035
			Trend = 0.037		Trend = 0.072
FEV1	1477
≥ 80%	1090	Referent		Referent
70–79%	227	1.26 (1.01 – 1.57)	0.038	1.23 (0.97 – 1.56)	0.086
60–69%	106	1.48 (1.10 – 2.01)	0.010	1.50 (1.06 – 2.13)	0.023
< 60%	54	2.02 (1.34 – 3.05)	0.001	2.23 (1.43 – 3.47)	<0.0005
			Trend <0.0005		Trend <0.0005
FVC	1477
≥ 80%	1205	Referent		Referent
70–79%	168	1.21 (0.94 – 1.56)	0.135	1.19 (0.91 – 1.56)	0.212
60–69%	71	1.27 (0.86 – 1.88)	0.230	1.29 (0.83 – 2.00)	0.253
< 60%	33	2.39 (1.48 – 3.86)	< 0.0005	2.49 (1.46 – 4.24)	0.001
			Trend = 0.001		Trend = 0.002
TLC	1381
≥ 80%	1220	Referent		Referent
70–79%	117	0.92 (0.66 – 1.29)	0.631	0.97 (0.69 – 1.37)	0.880
60–69%	34	1.31 (0.74 – 2.32)	0.357	1.58 (0.88 – 2.82)	0.124
< 60%	9	0.87 (0.26 – 2.88)	0.824	1.22 (0.31 – 4.76)	0.772
			Trend = 0.851		Trend = 0.343
DLCO	1375
≥ 80%	704	Referent		Referent
70–79%	307	0.96 (0.78 – 1.17)	0.661	0.97 (0.78 – 1.19)	0.751
60–69%	228	0.96 (0.75 – 1.23)	0.767	0.96 (0.73 – 1.25)	0.746
< 60%	135	1.23 (0.93 – 1.62)	0.156	1.22 (0.90 – 1.66)	0.206
			Trend = 0.431		Trend = 0.499

^*Adjusted for age, sex, disease risk, condition regimen, diagnosis of acute GVHD and pre-HCT lung function. Results do not include patients who had recurrent malignancy before pulmonary function was evaluated or patients diagnosed with chronic GVHD before or within one week of pulmonary function testing.