. Author manuscript; available in PMC: 2011 Jan 1.

Published in final edited form as: Cancer Prev Res (Phila). 2010 Jan;3(1):73–81. doi: 10.1158/1940-6207.CAPR-09-0151

Table 3.

Influence of celecoxib and piroxicam on oral cancer invasion score in rats treated with NQO

			Number (%) with lesion invasion score^*
Group	Agent	Agent Dose (mg/kg diet)	+1 Invasion	+2 Invasion	+3 Invasion
1	None (Control)	--	3/27 (11)	6/27 (22)	17/27 (63)
2	Celecoxib	500	7/27 (26)	2/27 (7)	10/27 (37)^†
3	Celecoxib	1500	5/28 (18)	12/28 (43)	4/28 (14)^†
4	Piroxicam	50	4/28 (14)	8/28 (29)	11/28 (39)^‡
5	Piroxicam	150	8/29 (28)	8/29 (28)	8/29 (28)^†
6	Zileuton	2000	3/25 (12)	4/25 (16)	17/25 (68)

Invasion Scores:

+1: extension through the mucosal epithelial basement membrane and into lamina propria only.
+2: extension into the upper muscle layers.
+3: extensive infiltration into the underlying muscle.

^†

p < 0.01 versus dietary control group.

^‡

0.05 < p < 0.10 versus dietary control group.