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. Author manuscript; available in PMC: 2010 Jan 12.
Published in final edited form as: J Immunol. 2006 Nov 15;177(10):7164–7172. doi: 10.4049/jimmunol.177.10.7164

FIGURE 5.

FIGURE 5

Effect of the IFN-STAT pathway on the expression of BAFF induced by dsRNA in BEAS-2B cells. A, BEAS-2B cells were pre-incubated with 0.01% DMSO or 0.1–10 mg/ml cycloheximide (CHX) for 1 h, and then stimulated with 25 μg/ml dsRNA for 3 h. B, BEAS-2B cells were preincubated with 0.1% DMSO or 0.1–10 μM JAKI for 1 h, and then stimulated with 25 μg/ml dsRNA for 6 h. C, BEAS-2B cells were transfected with siRNA against STAT1, IFNAR2, or control RNA at 5 or 20 nM for 72 h, and then stimulated with 1000 U/ml IFN-β and 25 μg/ml dsRNA for 6 h. The levels of BAFF and IFN-β mRNA were determined by real-time PCR. The results are shown as the mean ± SEM of four independent experiments. *, p < 0.05 vs dsRNA or IFN-β stimulated.