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. Author manuscript; available in PMC: 2010 Jan 12.
Published in final edited form as: J Alzheimers Dis. 2008 Apr;13(3):323–331. doi: 10.3233/jad-2008-13309

Figure 3.

Figure 3

Plasma Aβ42 levels (pg/ml) for (A) memory-impaired and (B) normal adults. Aβ42 levels increased for memory-impaired adults from saline to 10 IU regardless of ε4 status (p=.0213). For memory-impaired adults without the APOE-ε4 allele, Aβ42 levels at the highest insulin dose were greater than levels observed following saline administration (p=0.0071). Normal adults without the APOE-ε4 allele showed a U-shaped dose response curve, in which Aβ42 levels decreased in the 10 and 20 IU dose conditions compared with saline (ps=0.0585 and 0.0285).