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. Author manuscript; available in PMC: 2010 Jan 12.
Published in final edited form as: J Cell Physiol. 2008 Oct;217(1):13–22. doi: 10.1002/jcp.21445

Figure 5. Long term blockade of VEGF does not alter electroretinograms (ERGs).

Figure 5

Tet/IRBP/sVEGFR1Fc mice or littermate controls were given 2 mg/kg of doxycycline in their drinking water and after 7 months scoptopic (A) and photopic (B) ERGs were performed. The scotopic ERG wave forms appeared very similar in mice with chronic blockade of VEGF in the retina and controls (A, top row). There was no significant difference in mean a-wave or b-wave amplitude at any of the flash intensities tested (A, bottom row). Photopic ERG wave forms also appeared similar in mice with chronic blockade of VEGF in the retina and controls (B, left) and there was no significant difference in mean photopic b-wave amplitudes (B, right).