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. Author manuscript; available in PMC: 2010 Jan 12.
Published in final edited form as: J Cell Physiol. 2008 Oct;217(1):13–22. doi: 10.1002/jcp.21445

Figure 8. Chronic blockade of VEGF does not cause any reduction in ganglion cell axons.

Figure 8

Representative low (A,B) and high (C,D) magnification light micrographs of optic nerves from a Tet/IRBP/sVEGFR1Fc mouse treated with doxycycline for 7 months (VEGF blockade; A,C) and a littermate control mouse (B,D). No visible abnormalities were detected in either group. The number of axons per optic nerve was counted by image analysis and the bars represent the mean (± SEM) for each group (E). Statistical comparison by general linear model showed no difference.