Table 4.

Pharmacokinetic Variables in FSGS compared to Rheumatoid Arthritis

	Single Dose		Steady State
	FSGS	RA	FSGS
Tmax (hr)	55±62a	130±55&	34.2±9.8
Cmax (μg/mL)#	9.2±4.1a	13.7±2.7	12.8±8.3
T½ (hr)	159±155b	389±71	273±402
AUC (μg hr/mL)#	1649±1202b	3622±587	2019±1693
Cl/F (mL/hr)+	20.2±8.4b,c	11.2±2.0	53.2±43.3
Vd/z (L)	3.5±1.3b	5.7±0.9	6.6±5.4

Note: Data are provided as mean±SD. FSGS data are from the FONT study, rheumatoid arthritis (RA) values are from a previous study. 21

AUC data at single dose is 0-∞ and at steady state is 0-360 hours (represents a dosing interval)

^&Investigator Brochure cited in ref 21

^#normalized to a 40 mg dose

⁺body weight scaled to a power of 0.75 (ref 21)

^aP<0.02 comparing FSGS single dose and RA single dose

^bP<0.001 comparing FSGS single dose and RA single dose

^cP<0.05 comparing FSGS single dose and FSGS steady state