Skip to main content
. Author manuscript; available in PMC: 2010 Jan 12.
Published in final edited form as: Cancer Res. 2008 Jun 15;68(12):4559–4570. doi: 10.1158/0008-5472.CAN-08-0021

Figure 6. SRPK2 and acinus regulates cell cycle profile and leukemia cell proliferation.

Figure 6

(A). Ablation of acinus or SRPK2 attenuates cyclin A1 expression. Immunoblotting analysis of K562 cells transfected with siRNA of acinus or SRPK2. (B). Depletion of SRPK2 or acinus strongly decreases K562 cell proliferation. K562 cells were treated with a control RNAi, acinus RNAi, SRPK2 RNAi or Akt1 RNAi. The cells were stained with crystal violet 3 days after siRNA treatment. (C). Depletion of SRPK2 or acinus decreased Brdu incorporation. K562 cells treated with a control RNAi, acinus RNAi, SRPK2 RNAi or Akt1 RNAi. The cells were labeled with Brdu and stained 1 day after RNAi treatment. (D). Inactivation of acinus or SRPK2 induces G1 arrest in K562 cells. K562 cells were treated with various siRNA and the cell cycle profiles were analyzed with FACS.