FIG. 3.

Heritable T-cell malignancies are transplantable and can be easily visualized by fluorescent protein expression in leukemic cells (modified from Frazer et al.⁴¹). Green fluorescent protein (GFP⁺) leukemias from shrek (srk; A–C), hulk (hlk; D–F), and oscar the grouch (otg; G–I) mutants were transplanted into irradiated wild-type hosts. At 1 week, GFP⁺ cells were seen at the site of transplantation (A, D, G). Subsequently, tumors spread locally (B, E, H) and then disseminated widely (C, F, I).