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. Author manuscript; available in PMC: 2010 Jan 12.
Published in final edited form as: Science. 2008 Oct 17;322(5900):456–460. doi: 10.1126/science.1160311

Fig. 3.

Fig. 3

RNA devices based on signal integration at the ribozyme core (SI 2). Internal gates are indicated in dashed boxes, and triangles indicate relationships between associated internal gate inputs and outputs. (A) An RNA device that performs a NAND operation by coupling two internal Inverter gates responsive to different inputs to different ribozyme stems and the associated truth table. (B) The device response of a NAND gate (L1cm10 – L2bulgeOff3tc). Device response under different input conditions [theo or tc (−), 0 mM; theo (+), 10 mM; tc (+), 1 mM] is reported as in Fig. 2F. Error bars represent the SD from at least three independent experiments.