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. Author manuscript; available in PMC: 2010 Jan 12.
Published in final edited form as: Hum Mol Genet. 2007 Apr 4;16(10):1188–1200. doi: 10.1093/hmg/ddm066

Table 2.

Microarray expression studies on identifying Nrf2 (or NRF2)-regulated genes. The results of 4 microarray expression experiments were used to infer a set of NRF2-regulated genes in human by searching the HomoloGene database.

Tissue Genotype of transcription factor Treatment Up-regulated genes Reference
mouse (lung) Nrf2++ vs. Nrf2−− hyperoxia (oxidative stress) 65 (Basal) 175 (Inducible) Cho et al. 2005 (25)
mouse (intestine) Nrf2++ vs. Nrf2−− sulforaphane (activating Nrf2 pathway) 43 (Basal) 31 (Inducible) Thimmulappa et al. 2002 (39)
mouse (primary cortical astrocytes) Nrf2++ vs. Nrf2−− tert-butylhydroquinone (activating Nrf2 pathway) 73 (Basal) 75 (Inducible) Lee et al. 2003 (40)
human (neuroblastoma) NRF2++ tert-butylhydroquinone (activating NRF2 pathway) 63 (Inducible) Li et al. 2002 (32)