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. Author manuscript; available in PMC: 2010 Feb 15.
Published in final edited form as: Circ Res. 2008 Dec 18;104(3):380–387. doi: 10.1161/CIRCRESAHA.108.180695

Figure 4.

Figure 4

Intimal thickening and heparanase expression are increased with stenting in obese, hyperlipidemic Zucker rats. Endovascular stenting was performed through minimally invasive femoral access. (a) Histochemical staining and immunohistochemical staining of lean and obese Zucker rat aorta, 14 days after stent placement (n=16). EVG = Elastic Verhoff Van Geisen staining. Bar = 50 μm. (b) Analysis of neointimal thickness in lean and obese Zucker rats. (c) Quantitative analysis of heparanase in the neointima of lean and obese Zucker rats. (d) Heparanase expression and neointimal proliferation in response to endovascular stenting are enhanced in obese Zucker rats (■) compared to lean controls (○).The expression of heparanase within the neointima correlated strongly with the final neointimal area, giving a correlation of R=0.50 (p < 0.001) for lean rats and R=0.77 (p < 0.001) for fatty rats. *Statistically significant difference between samples (p < 0.05).