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. Author manuscript; available in PMC: 2010 Feb 15.

Published in final edited form as: Circ Res. 2008 Dec 18;104(3):380–387. doi: 10.1161/CIRCRESAHA.108.180695

Abdominal stenting of heparanase transgenic and wild type mice was performed using femoral access with small diameter self-expanding stents. Stents were harvested after 14 days and processed for histological analysis in resin sections. (a) Lateral x-ray of stent placement in the abdominal aorta of the mouse. The stent is visible just below the spine (marked with arrow). (b) Neointimal formation in response to vascular injury with endovascular staining is increased in heparanase transgenic mice. Staining for Mac-1 was increased in heparanase transgenic mice. Bar = 50 μm. (c–e) Morphological analysis of the stented arteries showed increased intimal area, intima to medial ratio and no change in media area for heparanase transgenic mice. (f) Concentration of MCP-1 in arterial lysates as measured by ELISA assay. The arteries were harvested one hour following arterial injury (n=4). ^*Statistically significant difference between all samples (p < 0.05).

Abdominal stenting of heparanase transgenic and wild type mice was performed using femoral access with small diameter self-expanding stents. Stents were harvested after 14 days and processed for histological analysis in resin sections. (a) Lateral x-ray of stent placement in the abdominal aorta of the mouse. The stent is visible just below the spine (marked with arrow). (b) Neointimal formation in response to vascular injury with endovascular staining is increased in heparanase transgenic mice. Staining for Mac-1 was increased in heparanase transgenic mice. Bar = 50 μm. (c–e) Morphological analysis of the stented arteries showed increased intimal area, intima to medial ratio and no change in media area for heparanase transgenic mice. (f) Concentration of MCP-1 in arterial lysates as measured by ELISA assay. The arteries were harvested one hour following arterial injury (n=4). ^*Statistically significant difference between all samples (p < 0.05).