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. Author manuscript; available in PMC: 2010 Jan 12.
Published in final edited form as: Chem Soc Rev. 2009 Sep 16;38(11):3175–3192. doi: 10.1039/b816697h

Table 2.

Summary of kinetic experiments carried out for the cyclizations of 36 and 44 in water at 45 °C (pH 7, 0.1 M potassium phosphate buffer).

graphic file with name nihms-166073-t0002.jpg graphic file with name nihms-166073-t0003.jpg
endo:exo 11.0 0.73
kobs (10−4, S−1) 0.47 7.16
t1/2 (h) 4.11 0.27
kH2O/kD2O 1.33 1.47
kinetic order in watera 1st and 2nd b 1st
a

determined in DMSO-d6/D2O mixtures.

b

70 °C.