The effect of Western-type diet (WD) on body weight in APOE3 (○) or APOE4 (■) mice over the experimental period (a), fecal fat excreted (b) and food intake (c). Weights of liver (d), subcutaneous adipose tissue (e) and epididymal adipose tissue (f) of 4-month-old mice fed regular chow (RC) or WD. (a) Statistical analysis was carried out by repeated measurements analysis of variance (ANOVA) using unweighted median analysis. Inset displays the number of mice weighed at each time point, APOE3 (upper row), APOE4 (bottom row). Analysis between subjects showed difference between alleles (P = 0.02). (b–f) Data are means±s.e.; n = 12–16, *P = 0.03 for the difference between groups.