TABLE 2.
Primer name | Clade | Subclade | % with correct clade(s) targeted | % with correct subclade (of correct clade) targeted | % with incorrect clade targeted | % not dmdAb | No. of sequences resampled | Normalized no. of dmdA clustersc |
---|---|---|---|---|---|---|---|---|
dmdAU | All | All | 94.0 | N/A | N/A | 6.0 | 400 | 51 |
A/1-sp | Clade A | Subclade 1 | 99.2 | 99.8 | 0.5 | 0.3 | 2,500 | 30 |
A/2-sp | Clade A | Subclade 2 | 98.7 | 97.8 | 0.3 | 1.0 | 3,500 | 25 |
A/2-dg | Clade A | Subclade 2 | 99.1 | 99.4 | 0.1 | 0.8 | 3,500 | 24 |
A/2-ino | Clade A | Subclade 2 | 99.4 | 99.4 | 0.05 | 0.5 | 3,500 | 20* |
B/3-sp | Clade B | Subclade 3 | 97.6 | 97.9 | 1.5 | 0.9 | 5,500 | 46 |
B/4-sp | Clade B | Subclade 4 | 33.6 | 99.3 | 65.4 | 0.9 | 1,500 | 20 |
C/2-sp | Clade C | Subclade 2 | 92.5 | 68.8 | 6.3 | 1.2 | 1,200 | 23 |
C/2-dg | Clade C | Subclade 2 | 64.2 | 81.8 | 33.8 | 2.0 | 1,200 | 35* |
C/2-ino | Clade C | Subclade 2 | 71.7 | 98.8 | 26.2 | 2.2 | 1,200 | 20 |
D/1-sp | Clade D | Subclade 1 | 88.4 | 97.8 | 0.5 | 11.2 | 6,000 | 200 |
D/3-sp | Clade D | Subclade 3 | 99.6 | 91.5 | 0.10 | 0.3 | 4,300 | 30 |
D/3-dg | Clade D | Subclade 3 | 95.3 | 96.7 | 4.6 | 0.1 | 4,300 | 32 |
D/all-sp | Clade D | All | 99.3d | N/A | 0.2 | 0.5 | 4,500 | 82 |
D/all-dg | Clade D | All | 99.9d | N/A | 0.1 | 0 | 4,500 | 68* |
D/all-ino | Clade D | All | 99.8d | N/A | 0 | 0.2 | 4,500 | 74* |
E/2-sp | Clade E | Subclade 2 | 96.65 | 99.99 | 1.58 | 1.77 | 3,000 | 43 |
E/2-dg | Clade E | Subclade 2 | 98.97 | 99.78 | 0.51 | 0.51 | 3,000 | 35* |
For particle-associated data, see Table S3 in the supplemental material. N/A, not applicable.
Includes sequences with hits to gcvT and those with no hits.
Average of 1,000 resamplings (see Materials and Methods) using the population sizes indicated in the “No. of sequences resampled” column. Cluster numbers marked with an asterisk were significantly different (P < 0.05) from that obtained by the specific version of that primer pair.
For the D/all-sp primer pair, 16.2% of the hits were to subclade D/1 and 2.5% to subclade D/3; for the D/all-dg primer pair, 13.8% of the hits were to subclade D/1 and 6.7% to subclade D/3; and for the D/all-ino primer pair, 4.4% of the hits were to subclade D/1 and 6.3% to subclade D/3. The remaining correct hits were to clade D sequences not classified within a subclade.