TABLE 4.
Locus tag | Predicted function (gene) | Fold valuea |
|||
---|---|---|---|---|---|
Δfur+Fe/WT+Fe | Δfur−Fe/WT−Fe | Δfur−Fe/Δfur+Fe | WT−Fe/WT+Fe | ||
Cell envelope | |||||
lmo0366 | Similar to putative lipoprotein involved in iron transport | 27.61 | 2.1 | — | 5.47 |
Energy metabolism | |||||
lmo0485 | Nitroreductase family protein | 3.83 | 1.65 | 1.61 | 2.17 |
lmo0943 | Nonheme iron-binding ferritin (fri) | 2.4 | 1.89 | 1.18 | 2.35 |
lmo1131 | Unknown, similar to ABC transporter, ATP-binding protein | 9.93 | 1.39 | — | 5.97 |
Hypothetical proteins | |||||
lmo0365 | Similar to high-affinity iron transporter | 25.03 | 2.43 | — | 5.58 |
lmo1007 | Unknown | 5.61 | — | — | 2.48 |
lmo2132 | Unknown | 2.04 | 1.4 | 1.26 | 2 |
lmo2181 | Sortase B (srtB) | 12.83 | 1.34 | −1.21 | 4.6 |
lmo2104 | Ferrous iron transport protein (A) | 15.17 | — | 1.22 | 7 |
lmo2105 | Ferrous iron transport protein (B) | 7.76 | 1.27 | — | 4.34 |
Regulatory functions | |||||
lmo1956 | Ferric uptake regulator | −12.75 | −3.25 | — | 1.44b |
Transport and binding proteins | |||||
lmo0541 | Similar to iron compound binding lipoprotein, ABC Transporter | 7.01 | — | — | 2.62 |
lmo1957 | Ferrichrome ABC transporter (permease) | 5.86 | 1.79 | −1.27 | 2.22 |
lmo1958 | Iron compound ABC transporter, permease protein (fhuB) | 4.7 | 1.44 | — | 2.01 |
lmo1960 | Iron compound ABC transporter (ATP binding) (fhuC) | 2.44 | — | — | 2.02 |
lmo2182 | Ferrichrome ABC transporter (ATP binding) | 13.3 | 1.34 | — | 3.97 |
lmo2183 | Ferrichrome ABC Transporter (permease) | 15.76 | 1.41 | — | 4.48 |
Unclassified | |||||
lmo0361 | Twin-arginine-targeting protein translocase (tatC) | 22.75 | 2.85 | −1.17 | 3.61 |
lmo0362 | Twin-arginine-targeting protein translocase (tatA) | 19.75 | 3.21 | −1.16 | 4.29 |
lmo2180 | Unknown, similar to GP157 family of protein | 4.09 | — | — | 4.71 |
lmo2185 | (svpA) | 8.91 | 1.58 | — | 2.99 |
lmo2186 | Unknown | 9.48 | — | — | 4.24 |
lmo0367 | Putative iron-dependent peroxidase | 25.83 | 1.57 | — | 4.07 |
Unknown function | |||||
lmo1961 | Similar to oxidoreductase | 3.58 | — | — | 2.4 |
Numbers in the fold value column are ratios of expression levels in the fur mutant (Δfur) and in the L. monocytogenes wild type (WT) in the presence of iron (+Fe) or in iron-limiting conditions (−Fe). —, no change or data not available.
Downregulated.