Figure 2.
Histology, microvessel density and cytokinetic properties of lung tumors. A. Lung lesions were analyzed for the frequency of hyperplasia, adenoma, and adenocarcinoma. B. Proliferation. Adenomas were analyzed for Ki-67 positive nuclei. C. Microvessel density. Shown is the number of CD31 positive pixels per tumor (resolved at 400x; n = 7, p=0.046, student’s t-test) in adenomas. D. Quantitative PCR analysis of VEGF in mouse lung tissue at baseline before NNK treatment. Shown is the quantity of total cellular and polyribosome bound VEGF RNA in arbitrary fluorescence units (n = 4, p= 0.0065, Wilcoxon rank sum test)
