Table 1.

Gene Ontology Analysis of all genes enriched in the polyribosome bound pool of 4ebp1^−/−/4ebp2^−/− mice (FDR < 5%)

Function	FDR	P - VALUE	ENRICHMENT
Growth and Metobolism
biopolymer metabolic process	0.00%	1.2E-07	1.51
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	0.00%	2.0E-06	1.57
RNA metabolic process	0.40%	1.7E-05	1.59
mRNA metabolic process	0.80%	1.3E-04	3.03
regulation of macromolecule metabolic process	1.09%	1.4E-04	1.54
regulation of cellular metabolic process	1.85%	2.2E-04	1.51
regulation of metabolic process	1.89%	2.9E-04	1.50
regulation of nucleoside, nucleotide and nucleic acid metabolic process	2.78%	5.1E-04	1.51
macromolecule biosynthetic process	0.50%	5.4E-05	1.50
biopolymer biosynthetic process	0.67%	3.7E-05	1.58
regulation of biosynthetic process	1.79%	3.0E-04	1.52
regulation of macromolecule biosynthetic process	2.13%	2.5E-04	1.53
RNA biosynthetic process	2.53%	6.8E-04	1.50
Proliferation
cell division	0.67%	7.2E-06	3.50
M phase of mitotic cell cycle	2.50%	7.7E-04	3.36
mitosis	2.55%	6.6E-04	3.43
mitotic cell cycle	4.39%	1.3E-03	2.79
cell cycle	4.51%	1.2E-03	1.89
chromosome condensation	4.54%	1.3E-03	12.73
Transcription
nucleic acid binding	0.00%	1.6E-06	1.60
nucleus	0.00%	1.6E-13	1.75
zinc ion binding	0.00%	2.9E-06	1.76
gene expression	0.50%	1.1E-05	1.55
regulation of gene expression	1.80%	4.3E-04	1.50
transcription	1.88%	2.5E-04	1.53
transcription, DNA-dependent	2.64%	6.4E-04	1.51
regulation of transcription	2.74%	5.9E-04	1.50
mRNA processing	0.44%	9.5E-05	3.28
RNA splicing	2.45%	7.1E-04	3.39
nuclear mRNA splicing, via spliceosome	2.46%	5.1E-04	3.54
RNA splicing, via transesterification reactions	2.67%	5.1E-04	3.54
RNA processing	2.71%	8.6E-04	2.37
RNA binding	4.00%	1.1E-03	2.06
Others
ribonucleoprotein complex assembly	2.00%	4.7E-04	4.95
protein prenyltransferase activity	4.11%	1.0E-03	8.49