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. Author manuscript; available in PMC: 2010 Jan 12.
Published in final edited form as: Angew Chem Int Ed Engl. 2009;48(34):6293–6295. doi: 10.1002/anie.200901992

Table 1.

Catalyst screening.a

graphic file with name nihms151258u1.jpg
Catalyst Yield of 1a [%] ee [%]b
1 [Rh(cod)(MeCN)2]BF4,(S)-BINAP 36 90
2 [Rh(cod)Cl]2, (S)-BINAP, AgOTf 60 91
3 [Rh(cod)Cl]2, (S)-BINAP, AgSbF6 65 95
4 [Rh((S)-BINAP)]SbF6 86 >99
a

Reactions were run in DCE (0.4 M) in the presence of 5–10 mol % catalyst at 23°C for 12–16 h.

b

Measured by chiral HPLC (OD-H column) after derivatization to the corresponding p-bromobenzoate ester. BINAP = 2,2′-bis(diphenylphosphino)-1,1′-binaphthalene, cod = 1,5-cyclooctadiene, DCE = 1,2-dichloroethane.