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. 2009 Nov 13;9(1):37–45. doi: 10.1128/EC.00186-09

FIG. 5.

FIG. 5.

Mutant schizonts expressing a compound 1-insensitive PfPKG progress through to ring stage normally in the presence of compound 1 in erythrocyte invasion assays. The proportions of ring parasitized RBCs in wild-type (WT) (A) and compound 1-insensitive (PfPKGT618Q) (B) parasite lines measured after treatment for 24 h with either compound 1, compound 2, staurosporine, or DMSO alone. Bars represent the mean proportion of triplicate samples. Error bars represent the mean binomial error of the proportions. The data were further analyzed in SPSS as for Fig. 1. The results marked with asterisks (**) showed a statistically significant reduction in rPRBCs from the DMSO control group [the 95% CI for Exp(B) did not include 1]. (C) Giemsa-stained smears of compound 1 and staurosporine-treated wild-type and PfPKGT618Q parasites. Scale bar, 5 μm.