Table A1.

Non Small-Cell Lung Cancer Level I Pathways for Study Timeframe

Pathway
Adjuvant, stage IB to IIIA
Paclitaxel/carboplatin
Cisplatin/VP-16
Unresected, stage IIIA to B
Paclitaxel/carboplatin
Cisplatin/VP-16
Best supportive care
Metastatic first line
Paclitaxel/carboplatin
Paclitaxel/carboplatin + bevacizumab (if nonsquamous, no brain metastases or hemoptysis, no history of bleeding, no anticoagulants)
Vinorelbine (if poor performance status)
Best supportive care
Metastatic second line
Pemetrexed
Docetaxel
Erlotinib
Best supportive care
Metastatic third line*
Erlotinib
Best supportive care

^*Chemotherapy beyond third line considered off Pathway.