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. 2009 Oct 19;587(Pt 23):5709–5721. doi: 10.1113/jphysiol.2009.181420

Figure 7. Effect of wortmannin on the TRH response.

Figure 7

A and B, current-clamp recordings showing the TRH-induced increase in spike frequency in the presence of 0.3 μm (A) or 50 μm (B) wortmannin. C, time course of the effect of TRH (300 nm) on the relative frequency of spontaneous action potentials. The number of spikes occurring every 30 s was normalized to that obtained before application of wortmannin and then plotted over time, in the presence of 0.3 μm (○) or 50 μm (•) wortmannin. The number of action potentials in the presence of 50 μm wortmannin between 8 and 20 min in this panel was significantly greater than that in 0.3 μm wortmannin (n= 6; P < 0.05).