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. Author manuscript; available in PMC: 2010 Dec 11.

Published in final edited form as: Vaccine. 2009 Oct 29;28(2):512–522. doi: 10.1016/j.vaccine.2009.09.127

Table 1.

Repeated injections with anti-4-1BB Ab, but not the SA-4-1BBL, results in significant alterations in absolute number of peripheral lymphocytes

	LN				Spleen
Treatment	CD8⁺ T cells^a	CD4⁺ T cells	CD19⁺ B cells	CD4⁺Foxp3⁺ T cells	CD8⁺ T cells	CD4⁺ T cells	CD19⁺ B cells	CD4⁺Foxp3⁺ T cells
None	1.89 ± 0.6	2.09 ± 0.7	2.45 ± 0.6	3.80 ± 0.8	10.39 ± 2.1	14.21 ± 1.4	56.99 ± 14.0	2.48 ± 0.5
SA	1.99 ± 0.3	2.25 ± 0.2	3.20 ± 0.5	3.67 ± 0.6	10.79 ± 2.6	15.89 ± 3.8	60.84 ± 13.8	2.53 ± 0.6
SA-4-1BBL	1.83 ± 0.7	2.21 ± 0.8	3.32 ± 1.2	3.38 ± 1.3	12.37 ± 1.9	17.38 ± 2.8	61.80 ± 9.4	2.75 ± 0.7
R-IgG	2.21 ± 0.5	2.66 ± 0.5	4.23 ± 0.6	4.01 ± 0.7	10.78 ± 0.5	17.36 ± 0.5	64.14 ± 7.4	2.45 ± 0.1
4-1BB Ab	8.20 ± 1.8^*	6.59 ± 1.4^*	13.14± 1.84^*	14.86 ± 3.7^*	23.43 ± 5.5^*	23.84 ± 3.4^*	35.49 ± 6.5^*	5.05 ± 1.7^*

^a

All numbers, except Treg cells in LN × 10⁵, are shown as × 10⁶ ± SD.

^*

p < 0.05, ANOVA, anti-4-1BB Ab vs. all other groups.