Table 2.
SNP | MAF | T1D association P |
P value conditional on the H5 haplotype |
---|---|---|---|
rs706778 | 0.439 (T) | 0.046 | 0.728 |
rs2104286 | 0.231 (C) | 6.56 × 10−4 | 0.552 |
rs3134883 | 0.322 (A) | 0.014 | 4.29 × 10−3 |
rs3118470 | 0.342 (C) | 4.43 × 10−3 | 3.37 × 10−3 |
rs7072793 | 0.443 (C) | 0.043 | 3.93 × 10−3 |
rs4749955 | 0.426 (C) | 1.10 × 10−3 | 9.90 × 10−4 |
rs12251307 | 0.099 (A) | 1.64 × 10−3 | 1.35 × 10−3 |
Abbreviations: MAF, minor allele frequency; SNP, single-nucleotide polymorphism; T1D, type I diabetes.
Results are based on the Illumina genotyping data. The conditioning analysis was done using the conditional extended TDT method,11 implemented in the UNPHASED software package (http://www.mrc-bsu.cam.ac.uk/personal/frank/software/unphased/).13 As shown by the conditioning analysis, five SNPs remain significant after conditioning on the H5 haplotype.