Table 4.

Colorectal cancer risk by MTHFR genotype and MSI status

SNP	MSS + MSI-L¥	p	MSI-H†	P	p-interaction§
rs11121832	1.04 (0.86–1.27)¶	0.66	1.05 (0.66–1.69)	0.23	0.97
rs12121543	0.94 (0.78–1.14)	0.54	0.97 (0.59–1.60)	0.83	0.91
rs12404124	0.96 (0.81–1.13)	0.61	0.90 (0.59–1.37)	0.61	0.77
rs13306556	1.03 (0.80–1.33)	0.83	0.93 (0.47–1.87)	0.85	0.79
rs1476413	0.97 (0.81–1.17)	0.75	1.05 (0.65–1.71)	0.83	0.74
rs17037390	0.88 (0.70–1.09)	0.25	0.76 (0.44–1.33)	0.34	0.64
rs17037396	0.97 (0.76–1.25)	0.84	1.11 (0.60–2.07)	0.74	0.69
rs17037425	0.95 (0.76–1.19)	0.65	0.82 (0.47–1.42)	0.48	0.63
rs17421462	1.25 (0.92–1.70)	0.16	1.00 (0.53–1.87)	0.99	0.56
rs17421511	0.97 (0.77–1.20)	0.75	1.08 (0.63–1.85)	0.78	0.71
rs1801131*	0.77 (0.54–1.08)	0.13	0.51 (0.24–1.08)	0.08	0.36
rs1801133*	0.69 (0.50–0.97)	0.03	2.22 (0.91–5.43)	0.08	0.01
rs1994798	0.94 (0.80–1.11)	0.50	0.85 (0.55–1.31)	0.47	0.65
rs3737964	1.01 (0.83–1.22)	0.92	1.08 (0.68–1.72)	0.75	0.80
rs3737965	0.98 (0.70–1.39)	0.92	0.81 (0.33–2.00)	0.66	0.69
rs4846048	0.94 (0.78–1.13)	0.52	0.92 (0.59–1.43)	0.71	0.93
rs4846049	0.91 (0.76–1.08)	0.27	0.85 (0.54–1.35)	0.49	0.79
rs4846054	0.99 (0.84–1.17)	0.88	0.91 (0.59–1.40)	0.68	0.74
rs6541003	0.98 (0.83–1.16)	0.86	0.87 (0.57–1.34)	0.54	0.61
rs9651118	1.07 (0.88–1.30)	0.48	0.68 (0.41–1.12)	0.13	0.12
rs17376328	0.86 (0.59–1.25)	0.43	1.41 (0.58–3.45)	0.45	0.32
rs2050265	0.87 (0.69–1.08)	0.21	0.90 (0.51–1.58)	0.71	0.91

^¥Based on a minimum of 958 cases and 1532 controls from 931 discordant sibships.

^†Based on a minimum of 175 cases and 255 controls from 166 discordant sibships.

^§p-value for the multiplicative interaction term (MSI status * genotype (coded as 0, 1 or 2 for the presence of the minor allele)).

^¶Except as noted all OR’s were estimated assuming a log-additive model and controlling for age and sex.

^*ORs estimated from a recessive model and controlling for age and sex.