Table 2.
Genotype-specific risks for pancreatic cancer
| Locus | Chr | SNP | OR (95%CI) | Ptrend | Adjusted OR* (95%CI) |
Ptrend |
|---|---|---|---|---|---|---|
| DOCK7 | 1 | rs1748197 | 1.02 (0.9, 1.16) | 0.76 | 1.03 (0.90, 1.17) | 0.67 |
| GPSM2 | 1 | rs12090453 | 1.08 (0.96, 1.22) | 0.19 | 1.07 (0.94, 1.21) | 0.31 |
| NEK7 | 1 | rs2884765 | 0.90 (0.73, 1.10) | 0.30 | 0.91 (0.73, 1.12) | 0.36 |
| RRM2 | 2 | rs6759180 | 0.98 (0.86, 1.12) | 0.78 | 0.99 (0.87, 1.13) | 0.85 |
| SMC6L | 2 | rs6743259 | 0.99 (0.74, 1.31) | 0.93 | 1.00 (0.75, 1.34) | 0.99 |
| RYK | 3 | rs9283588 | 0.95 (0.79, 1.14) | 0.58 | 0.95 (0.79, 1.14) | 0.58 |
| TOPBP1 | 3 | rs10935070 | 0.99 (0.87, 1.12) | 0.81 | 0.98 (0.86, 1.11) | 0.70 |
| TACC3 | 4 | rs1374468 | 0.99 (0.86, 1.15) | 0.94 | 0.96 (0.82, 1.11) | 0.56 |
| APC | 5 | rs2431238 | 1.14 (1.01, 1.30) | 0.035 | 1.14 (1.00, 1.29) | 0.05 |
| PLK2 | 5 | rs697141 | 1.03 (0.90, 1.17) | 0.72 | 1.04 (0.91, 1.19) | 0.54 |
| FYN | 6 | rs1465061 | 0.91 (0.81, 1.03) | 0.13 | 0.91 (0.80, 1.03) | 0.12 |
| RIPK1 | 6 | rs12209182 | 1.09 (0.97, 1.23) | 0.16 | 1.08 (0.96, 1.22) | 0.21 |
| MCPH1 | 8 | rs2433149 | 1.10 (0.97, 1.25) | 0.13 | 1.09 (0.95, 1.24) | 0.22 |
| RAD21 | 8 | rs4579555 | 1.12 (0.93, 1.35) | 0.25 | 1.10 (0.91, 1.34) | 0.33 |
| CDC37 | 9 | rs5022070 | 1.01 (0.89, 1.14) | 0.89 | 1.02 (0.90, 1.15) | 0.78 |
| EIF3S10 | 10 | rs10787899 | 1.06 (0.94, 1.19) | 0.37 | 1.02 (0.90, 1.15) | 0.74 |
| KIAA0999 | 11 | rs7928320 | 0.96 (0.83, 1.11) | 0.55 | 0.97 (0.84, 1.12) | 0.68 |
| SART1 | 11 | rs679581 | 1.04 (0.93, 1.17) | 0.50 | 1.06 (0.93, 1.20) | 0.38 |
| CDC16 | 13 | rs7998576 | 1.03 (0.90, 1.18) | 0.70 | 1.02 (0.89, 1.18) | 0.76 |
| NIN | 14 | rs9788504 | 0.93 (0.83, 1.05) | 0.25 | 0.94 (0.83, 1.06) | 0.33 |
| NIN | 14 | rs10145182 | 0.88 (0.78, 0.99) | 0.038 | 0.89 (0.79, 1.01) | 0.06 |
| SNW1 | 14 | rs1477261 | 0.93 (0.80, 1.09) | 0.36 | 0.95 (0.84, 1.11) | 0.54 |
| MAP2K1 | 15 | rs7181936 | 0.89 (0.79, 1.01) | 0.06 | 0.91 (0.80, 1.03) | 0.13 |
| PRC1 | 15 | rs10520699 | 1.13 (0.95, 1.35) | 0.18 | 1.12 (0.93, 1.34) | 0.23 |
| AXIN2 | 17 | rs11079571 | 0.98 (0.84, 1.15) | 0.82 | 0.95 (0.81, 1.11) | 0.51 |
| PRKCA | 17 | rs7342847 | 0.90 (0.80, 1.02) | 0.09 | 0.92 (0.81, 1.03) | 0.16 |
| TEX14 | 17 | rs302864 | 0.92 (0.75, 1.13) | 0.44 | 0.88 (0.71, 1.09) | 0.23 |
| TLK2 | 17 | rs2245092 | 0.99 (0.88, 1.13) | 0.94 | 1.01 (0.89, 1.14) | 0.91 |
| TUBG1 | 17 | rs2134808 | 1.02 (0.89, 1.17) | 0.76 | 1.02 (0.88, 1.17) | 0.82 |
| YPEL2 | 17 | rs12936897 | 1.06 (0.95, 1.20) | 0.30 | 1.07 (0.94, 1.21) | 0.30 |
| ROCK1 | 18 | rs17202375 | 1.09 (0.89, 1.34) | 0.41 | 1.06 (0.85, 1.31) | 0.60 |
| CABLES2 | 20 | rs8668 | 1.08 (0.95, 1.23) | 0.27 | 1.08 (0.94, 1.23) | 0.28 |
| SUMO3 | 21 | rs2017089 | 1.01 (0.85, 1.19) | 0.95 | 1.01 (0.85, 1.20) | 0.94 |
*
OR and 95%CI after adjustment for age at diagnosis, gender, ever/never smoking, BMI and family history of pancreatic cancer.