Table 3.
Genotype specific risks of pancreatic cancer in subgroups based on BMI and smoking
| Gene | SNP | Strata | Cases | Controls | OR (95%CI) |
Ptrend |
|---|---|---|---|---|---|---|
| TOPBP1 | rs10935070 | Current smoker |
148 | 41 | 2.35 (1.26, 4.35) |
0.007 |
| Pack-years <20 |
186 | 284 | 1.35 (1.03, 1.79) |
0.03 | ||
| APC | rs2431238 | BMI >=30 | 374 | 239 | 1.31 (1.02, 1.67) |
0.031 |
| PLK2 | rs697141 | Pack-years <20 |
186 | 284 | 1.43 (1.07, 1.92) |
0.016 |
| FYN | rs1465061 | Pack-years >=40 |
135 | 77 | 0.59 (0.39, 0.91) |
0.016 |
| RIPK1 | rs12209182 | Non-smoker | 455 | 592 | 1.22 (1.02, 1.44) |
0.027 |
| MCPH1 | rs2433149 | Ever-smoker | 682 | 505 | 1.20 (1.00, 1.43) |
0.044 |
| Former smoker |
527 | 458 | 1.22 (1.01, 1.47) |
0.044 | ||
| BMI <30 | 769 | 858 | 1.17 (1.01, 1.35) |
0.042 | ||
| RAD21 | rs4579555 | Non-smoker | 455 | 592 | 1.50 (1.14, 1.96) |
0.003 |
| NIN | rs10145182 | Ever smoker | 682 | 505 | 0.82 (0.69, 0.97) |
0.01 |
| SNW1 | rs1477261 | Pack-years <20 |
186 | 284 | 0.61 (0.43, 0.87) |
0.006 |
| MAP2K1 | rs7181936 | BMI <30 | 769 | 858 | 0.86 (0.75, 1.00) |
0.049 |
| PRC1 | rs10520699 | BMI >=30 | 374 | 239 | 1.52 (1.05, 2.22) |
0.028 |
| PRKCA | rs7342847 | Current smoker |
148 | 41 | 0.53 (0.31, 0.89) |
0.017 |
| BMI >=30 | 374 | 239 | 0.78 (0.61, 0.99) |
0.041 | ||
| TEX14 | rs302864 | BMI >=30 | 374 | 239 | 0.67 (0.46, 0.98) |
0.036 |
| YPEL2 | rs12936897 | BMI >=30 | 374 | 239 | 1.27 (1.00, 1.62) |
0.048 |
Analyses were adjusted for age at diagnosis, sex, and smoking history (ever, never)