Table 4.
Genotype specific associations with pancreatic cancer survival
| Cancer status | Gene | SNP | Overall survival | |
|---|---|---|---|---|
| HR (95% CI) | P-value | |||
| Overall | ||||
| EIF3S10 | rs10787899 | 1.22 (1.05, 1.41) | 0.009 | |
| Resected | ||||
| GPSM2 | rs12090453 | 0.64 (0.47, 0.88) | 0.006 | |
| KIAA0999 | rs7928320 | 0.68 (0.49, 0.95) | 0.022 | |
| TUBG1 | rs2134808 | 1.41 (1.04, 1.91) | 0.026 | |
| TEX14 | rs302864 | 0.59 (0.38, 0.91) | 0.017 | |
| AXIN2 | rs11079571 | 0.61 (0.44, 0.86) | 0.005 | |
| Locally advanced |
||||
| APC | rs2431238 | 0.75 (0.59, 0.95) | 0.017 | |
| TLK2 | rs2245092 | 1.3 (1.03, 1.65) | 0.027 | |
Survival time was based on date of diagnosis to date of death/last contact. Analyses were adjusted for age at diagnosis, sex, and stage of disease (resected, locally advanced, metastatic).