Table 2.

Odds and 95% CI of adverse pathological features stratified by race and obesity^* among men with diabetes at surgery

	No. total patients	No. diabetics	Odds Ratio** (95% CI)	p	p – interaction: by race†	p – interaction: by obesity††
High Grade Disease
Overall	1262	233	1.73 (1.22 - 2.45)	0.002	0.17
White	670	103	2.28 (1.33 - 3.91)	0.003		0.47
Non Obese	488	58	2.08 (1.07 - 4.05)	0.03
Obese	182	45	2.52 (0.96 - 6.60)	0.06
Black	592	130	1.45 (0.90 - 2.33)	0.13		0.88
Non Obese	406	72	1.48 (0.80 - 2.73)	0.21
Obese	186	58	1.56 (0.71 - 3.44)	0.27
ECE
Overall	1262	233	1.25 (0.85 - 1.83)	0.27	0.49
White	670	103	0.93 (0.53 - 1.63)	0.81		0.94
Non Obese	488	58	1.04 (0.50 - 2.19)	0.91
Obese	182	45	0.68 (0.27 - 1.70)	0.41
Black	592	130	1.64 (0.94 - 2.85)	0.08		0.41
Non Obese	406	72	2.00 (1.02 - 3.94)	0.04
Obese	186	58	1.25 (0.43 - 3.66)	0.68
PSM
Overall	1262	233	1.11 (0.81 - 1.52)	0.50	0.3
White	670	103	1.31 (0.82 - 2.10)	0.25		0.07
Non Obese	488	58	0.92 (0.50 - 1.71)	0.79
Obese	182	45	2.07 (0.93 - 4.59)	0.08
Black	592	130	1.01 (0.65 - 1.55)	0.98		0.32
Non Obese	406	72	0.86 (0.49 - 1.53)	0.61
Obese	186	58	1.28 (0.63 - 2.59)	0.50
SVI
Overall	1262	233	1.73 (1.04 - 2.90)	0.04	0.78
White	670	103	1.44 (0.64 - 3.25)	0.38		0.35
Non Obese	488	58	1.16 (0.36 - 3.80)	0.80
Obese	182	45	1.31 (0.37 - 4.66)	0.67
Black	592	130	2.01 (1.02 - 3.99)	0.05		0.18
Non Obese	406	72	2.78 (1.21 - 6.40)	0.02
Obese	186	58	0.93 (0.26 - 3.38)	0.92

ECE – extracapsular extension, PSM – positive surgical margins SVI – seminal vesicle invasion

^*Obesity was defined as a BMI ≥ 30 kg/m²

^**Adjusted for age, year of surgery, race, BMI, clinical stage, biopsy Gleason score (except analysis of high-grade disease), center, and pre-operative PSA

^†p – interaction by race assessed by including the cross product term between diabetes and race in the model

^††p – interaction by obesity assessed by including the cross product term between obesity and race in the model