Figure 1.

Time course of average free testosterone (A) and estradiol (B) levels. Older men are shown in solid lines and younger men in dotted lines. Black arrows depict the timing of the lupron shots. Cognitive testing occurred on the second (V2, pretreatment) and ninth (V9 posttreatment) study visits. The intervals among study visits varied based on the goal of the study visit, and the irregular intervals are delineated by slash marks on the x-axis. V1–V2 was the time between screening and the first study and averaged 20.7 d (sd 14.9), V3 was 4.0 (sd 1.1.) d later to monitor the effects of medication, V4 completed the first study week (4.2 d; 1.9 sd from V3) and was followed by weekly study visits to obtain hormone levels and monitor health thereafter (V5, 6, 7, 8, and 9). This was followed by a safety visit (V10) to ensure that testosterone levels had returned to prestudy, normal values, and the V10 visit was repeated if normal levels were not obtained. The time from V9 to V10 visit that yielded normal levels was 51.1 d (sd 18.6).