Table 2.
Hormone levels
| Treatment group | n | Free testosterone (pmol/liter)
|
Estradiol (pg/ml)
|
||
|---|---|---|---|---|---|
| V2, pre-Tx | V9, post-Tx | V2, pre-Tx | V9, post-Tx | ||
| Old | |||||
| 1. GnRH agonist, T-gel | 15 | 241.4ac (65.5) | 347.6a (155.2) | 17.1 (5.3) | 19.1a (6.4) |
| 2. GnRH agonist, T-gel, Arimidex | 17 | 278.1ac (70.8) | 390.1a (147.1) | 20.2b (4.4) | 8.6b (3.7) |
| 3. GnRH agonist, placebo gel | 15 | 224.9bb (60.4) | 10.2b (18.2) | 17.8b (4.7) | 10.6b (3.2) |
| 4. Placebo | 15 | 246.4a (80.9) | 233.9c (63.6) | 17.6 (5.3) | 17.5a (4.0) |
| Effect of treatment group within visit | P = 0.19 | P < 0.001 | P = 0.29 | P < 0.001 | |
| Young | |||||
| 1. GnRH agonist, T-gel | 8 | 411.0 (125.8) | 541.9a (310.2) | 24.0 (6.2) | 24.8a (7.8) |
| 2. GnRH agonist, T-gel, Arimidex | 5 | 342.8 (96.2) | 366.7a (104.3) | 21.1a (4.8) | 10.8b (2.4) |
| 3. GnRH agonist, placebo gel | 8 | 377.9b (85.7) | 6.6b (6.0) | 26.6b (8.5) | 15.8b,c (5.4) |
| 4. Placebo | 5 | 361.7 (97.4) | 561.3a (329.1) | 19.5 (4.6) | 22.3a,c (4.7) |
| Effect of treatment group within visit | P = 0.69 | P < 0.001 | P = 0.26 | P = 0.001 | |
Data represent mean (sd). T-gel, Testosterone gel; pre-Tx, pretreatment; post-Tx, posttreatment. Different letter subscripts indicate significant, between-group post hoc differences within age group at P < 0.05. All subscripts reflect uncorrected post hoc P values.
a
P < 0.05 for comparisons within age groups where pre-Tx > post-Tx.
b
P < 0.001 for comparisons within age groups where pre-Tx > post-Tx.
c
P < 0.05 for comparisons within age groups where pre-Tx < post-Tx.