Table 3.

Effect of antisense oligonucleotides to PRKX on M-CSF-induced macrophage maturation of human peripheral blood monocytes

Monocytes treated with	Adherent and spread cells, %	Phagocytic cells, %
—	12  ±  7	48  ±  5
M-CSF	53  ±  11	89  ±  5
M-CSF + SENSE1	57  ±  8	92  ±  5
M-CSF + ANTISENSE1	17  ±  6	43  ±  5
M-CSF + SENSE2	52  ±  9	89  ±  7
M-CSF + ANTISENSE2	15  ±  6	46  ±  3

In the absence of the differentiation inducers, the oligonucleotides neither affected cell proliferation nor induced appearance of any maturation markers. The data represent the mean results of three independent experiments ± SD.