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Proposed roles of AKR1C enzymes in prostate cancer, breast cancer and myeloid leukaemia. AR, androgen receptor. ER, estrogen receptor. CYP19arom, CYP19 aromatase. PG, prostaglandin. 15d-PGJ2, 15-deoxy-Δ12,14-PGJ2. ROS, reactive oxygen species. PPARγ, peroxisome proliferator-activated receptor γ. NF-κB, nuclear factor κB.
