Table 1.
Subject Demographics
| Characteristic | UHR Patients (n = 36) | Healthy Controls (n = 25) |
|---|---|---|
| Age at baseline examination, mean (±SD) | 17.02 (3.37) | 17.96 (3.40) |
| Years of Education, mean (± SD) | 10.66 (2.54) | 11.84 (2.77) |
| Parental Education (years), mean (± SD) | ||
| Estimated WASI IQ, mean (± SD)a | 110.58 (13.52) | 111.82 (11.29) |
| Gender, n (%) | ||
| Males | 27 (75%) | 12 (48%) |
| Females | 9 (25%) | 13 (52%) |
| Race, n (%) | ||
| African American/Black | 5 (14%) | 3 (12%) |
| Asian American/Pacific Islander | 3 (8%) | 3 (12%) |
| Caucasian | 22 (61%) | 13 (52%) |
| Native American | 0 (0%) | 1 (4%) |
| Latino/Hispanic | 4 (11%) | 4 (16%) |
| Other | 2 (6 %) | 1 (4%) |
| Handedness, b n (%) | ||
| Left or Mixed/Right | 3 (9%) | 2 (10%) |
| Primary SIPS-defined Prodromal Status, n (%) | ||
| Brief Intermittent Psychotic Syndrome | 7 (19%) | |
| Attenuated Positive Symptom Syndrome | 28 (78%) | |
| Genetic Risk & Deterioration Syndrome | 1 (3%) | |
| Diagnosis of Schizotypal Personality Disorder, n | 1 | |
| Family History of Psychotic Disorder (First-degree relative), n | 8 | |
| Clinical Characteristics of Sample | ||
| GAF score, mean (± SD) Baseline | 45.25 (15.02) | |
| Follow-up 1 | 56.15 (13.59) | |
| Follow-up 2 | 60.38 (15.47) | |
| SOPS Positive Symptom Total, mean (± SD) Baseline | 10.69 (4.34) | |
| Follow-up 1 | 7.96 (4.85) | |
| Follow-up 2 | 7.92 (2.3) | |
| SOPS Negative Symptom Total, mean (±SD) Baseline | 10.75 (6.68) | |
| Follow-up 1 | 10.25 (7.15) | |
| Follow-up 2 | 8.76 (9.54) | |
| Global Functioning: Role score, mean (±SD) Baseline | 6.38 (1.72) | |
| Follow-up 1 | 6.37 (1.86) | |
| Follow-up 2 | 6.07 (2.28) | |
| Global Functioning: Social score, mean (±SD) Baseline | 6.22 (1.56) | |
| Follow-up 1 | 6.37 (1.96) | |
| Follow-up 2 | 6.76 (2.12) | |
| Conversion to DSM Diagnosis of Psychotic Disorder n (%) | 6 (17%) | |
| Medication usage at baseline DTI scan, n (%) | 21 (58%) | |
| Atypical Antipsychotics, n (%) | 9 (25%) | |
| SSRIs, n (%) | 12 (33%) | |
a
IQ and handedness data were missing for 3 control subjects
b
Gender differed significantly between groups (χ2=5.44, p=.02)