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. 2010 Jan 13;5(1):e8219. doi: 10.1371/journal.pone.0008219

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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Panel A shows the observed LD decay compared to background LD across 40 kb. LD was calculated as the median r² in bins of 1000 comparisons. The background LD is the median r² from 20,000 comparisons between SNPs on different chromosomes. Panel B shows the –log10 p-values from comparing the distribution of observed r² values within each bin to the distribution of background r² values generated from comparisons between SNPs on different chromosomes using a Mann-Whitney U test (see Methods for details).