Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2010 Jan 13;5(1):e8689. doi: 10.1371/journal.pone.0008689

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Becker et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

PMC Copyright notice

(A) Ovine PITX3 gene structure. (B) Electropherograms of the PITX3 c. 338G>C mutation. Representative sequence traces of PCR products amplified from genomic DNA of three sheep with the different genotypes are shown. (C) Multispecies alignment of the evolutionary conserved homeodomain of the PITX3 protein sequence. The p.R113P mutation in PITX3is indicated by an arrow. It affects an arginine residue, which is perfectly conserved from human to zebrafish across all investigated species. The sequences for the alignment were taken from the following accessions: (sheep, NP_005020 (human), XP_589431 (cattle), XP_001499185 (horse), EDL41981 (mouse), NP_062120 (rat), XP_421631 (chicken), NP_001082023 (Xenopus laevis), NP_991238 (Danio rerio).