Figure 2.

Comparative genomic hybridization (CGH) array results and proposed structure of a 111 kb amplification. (A) Hybridization to an Agilent 244K CGH array allowed breakpoints to be positioned within TFG intron 3 and GPR128 intron 1. The log₂ ratio of signals within the amplification suggested two additional copies of the CNV region. (B) Non-rearranged GPR128 lies upstream of TFG (top). The CNV amplification, with breakpoints within TFG and GPR128, results in one (middle) or two (bottom) copies of the TFG-GPR128 fusion gene. Arrows show direction of transcription.