Figure 1.
Hematoxylin-eosin and silver staining of bone marrow biopsies from three patients aged 16 (A and B), 43 (C and D) and 69 years (E and F), affected by hereditary thrombocythemia due to the MPLSer505Asn mutation. A: shows a slightly hypercellular bone marrow with an increase in the number of neutrophils and atypical megakaryocytes with deviations from the normal nuclear:cytoplasmic ratio and the frequent occurrence of bare megakaryocytic nuclei. B: reticulin fibrosis is absent. C: shows a hypercellular bone marrow with an increase in the number of atypical megakaryocytes that form dense clusters. D: loose network of reticulin with many intersections. E, F: shows a bone marrow biopsy mainly characterized by a diffuse increase in reticulin with focal bundles of collagen and with numerous distorted megakaryocytes. A-F 250×.