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. Author manuscript; available in PMC: 2010 Dec 29.
Published in final edited form as: Curr Biol. 2009 Dec 3;19(24):2086–2090. doi: 10.1016/j.cub.2009.10.051

Figure 4. Inhibition of skin reinnervation by injured axons is mediated by the NgR/RhoA pathway.

Figure 4

(A–C) Tracing overlays as in Figure 2. Arrowhead is site of axotomy, olive marks denervated territory, and scale bars = 50 μm. 78 hpf axotomy of a trigeminal neuron expressing GFP and RFP (A), DN NgR (B), or DN RhoA (C). (D) Quantification of fraction of axons that entered the denervated territory. Data to the left of the double bar were from axons expressing GFP and dominant negative or full length versions of the genes indicated. Data to the right of the double bar were from Tg(sensory:GFP) embryos injected with indicated morpholinos. Red indicates fraction of axons that grew into denervated territory, blue indicates axons that avoided denervated territory (See supplemental methods). See Table S2 and Movies S11–S13.