Skip to main content
. Author manuscript; available in PMC: 2010 Dec 1.
Published in final edited form as: FEBS J. 2009 Oct 16;276(23):6844–6856. doi: 10.1111/j.1742-4658.2009.07378.x

Scheme 2.

Scheme 2

Canonical cholesterol catabolism pathway [44] based on studies in Rhodococcus [100], C. testosteroni [46, 101] and fast-growing mycobacteria [102]. It is believed that the cholesterol derivatives 2 and 3 are both substrates for the C26 hydroxylation enzyme. The cholesterol side chain β-oxidation intermediates are potential substrates for KstD and KshA/B. The preferred substrates have not been established.