Table 2.

Cardiovascular Drugs Interacting with Antiviral Therapy [49]

Cardiovascular medications that interact with anti-retrovirals

Dihydropyridine calcium-channel blockers

Sildenafil

β-Blockers, digoxin, and non-dihydropyridine calcium-channel blockers

Statins Metabolized by CYP3A4: atorvastatin, lovastatin, simvastatin, Not metabolized by CYP3A4: fluvastatin, pravastatin

Anticoagulants- warfarin, antiarrhythmics- amiodarone, antiplatelets- ASA, clopidogrel

Drugs used in HIV positive individuals that interact with cardiovascular drugs

Protease Inhibitors (PI’s)- some act as substrates, CYP enzyme inhibitor/ inducers

Nucleoside reverse transcriptase inhibitors (NRTI)-some act as substrates. CYP enzyme inhibitor/ inducers

Non-nucleotide reverse transciptase inhibitors (NNRTI)- some act as substrates. CYP enzyme inhibitor/inducers

Antibiotics- Cotrimoxazole, anti-virals- class of acyclovir, anti-fungalsazoles

Anti-tuberculous therapy