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. 2010 Jan 5;102(3):561–569. doi: 10.1038/sj.bjc.6605491

Figure 4.

Figure 4

Circulating tumour cells (CTCs) demonstrate greater colony formation capabilities in chronic hypoxia compared with parental MDA-MB-231 cells and grow larger and heavier tumours. (A) Colonies grown from CTCs incubated in normoxia and chronic hypoxia compared with colonies grown from parental MDA-MB-231 cells after 10 days (graph shows mean numbers±s.e.). (Bi) Comparing sizes of xenogafts generated from CTCs with xenografts generated from MDA-MB-231 cells within 3–6 weeks of growth (graph represents mean volume±s.e., n=5); (Bii) comparing size and weight of xenografts from CTCs with xenografts from MDA-MB-231 cells at 3 and 6 weeks (graphs represent mean weight±s.e.). N, normoxia; H, hypoxia.