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The effect of STAT3-C expression on LLL12-mediated inhibition in U87 glioblastoma cells. Cells were transfected with a vector expressing constitutively active STAT3, STAT3-C for 24 hours, then treated with LLL12 for another 24 hours. (A) LLL12-induced caspase-3 cleavage was rescued in U87 cells when STAT3-C protein was expressed. (B) The inhibition of cell viability of LLL12 in U87 cells was also reduced in the presence of STAT3-C protein in MTT assay (*P < .05).
