Table 2.
Amino Acid Metabolism-Related Gene Whose Expression Is Modified in TMZ LTT Hs683 Cells.
| Gene Symbol | Gene Name | Hs683 TMZ-S | Hs683 TMZ-LTT | Ratio TMZ-S/TMZ-LTT |
| Genes downregulated in TMZ-LTT Hs683 cells | ||||
| HPD | 4-Hydroxyphenylpyruvate dioxygenase | 258 | 15 | 12.9 |
| BCAT1 | Branched chain aminotransferase 1, cytosolic | 345 | 25 | 12.8 |
| CPS1 | Carbamoyl-phosphate synthetase 1, mitochondrial | 1849 | 277 | 5.2 |
| CBS | Cystathionine-β-synthase | 263 | 56 | 4.3 |
| PSAT1 | Phosphoserine aminotransferase 1 | 3735 | 996 | 3.7 |
| WARS | Tryptophanyl-tRNA synthetase | 1074 | 286 | 3.5 |
| GFPT1 | Glutamine-fructose-6-phosphate transaminase 1 | 1822 | 495 | 3.4 |
| SLC3A1 | Solute carrier family 3, member 1 | 28 | 8 | 3.3 |
| PSPH | Phosphoserine phosphatase | 564 | 174 | 3.2 |
| ASNS | Asparagine synthetase | 4167 | 1214 | 3.2 |
| IDS | Iduronate 2-sulfatase (Hunter syndrome) | 215 | 65 | 3.1 |
| CTPS | CTP synthase | 878 | 295 | 3.0 |
| WWOX | WW domain containing oxidoreductase | 190 | 66 | 2.9 |
| GSTZ1 | Glutathione transferase zeta 1 (maleylacetoacetate isomerase) | 253 | 92 | 2.6 |
| MARS | Methionine-tRNA synthetase | 1988 | 768 | 2.6 |
| AARS | Alanyl-tRNA synthetase | 2875 | 1014 | 2.5 |
| HYOU1 | Hypoxia-upregulated 1 | 1624 | 535 | 2.5 |
| GAMT | Guanidinoacetate N-methyltransferase | 111 | 43 | 2.5 |
| ARSJ | Arylsulfatase family, member J | 74 | 18 | 2.5 |
| ARG2 | Arginase, type II | 77 | 26 | 2.4 |
| CARS | Cysteinyl-tRNA synthetase | 537 | 203 | 2.3 |
| DIO1 | Deiodinase, iodothyronine, type 1 | 22 | 9 | 2.2 |
| AGMAT | Agmatine ureohydrolase (agmatinase) | 258 | 96 | 2.1 |
| HSD17B6 | Hydroxysteroid (17-β) dehydrogenase 6 | 32 | 14 | 2.1 |
| ABAT | 4-Aminobutyrate aminotransferase | 48 | 20 | 2.1 |
| PHGDH | Phosphoglycerate dehydrogenase | 785 | 348 | 2.1 |
| GARS | Glycyl-tRNA synthetase | 4951 | 2247 | 2.0 |
| DDC | Dopa decarboxylase (aromatic L-amino acid decarboxylase) | 277 | 131 | 2.0 |
| Genes upregulated in TMZ-LTT Hs683 cells | ||||
| GLCE | Glucuronic acid epimerase | 247 | 885 | 0.30 |
| SULT1C1 | Sulfotransferase family, cytosolic, 1C, member 1 | 10 | 33 | 0.30 |
| ARHGAP24 | Rho GTPase activating protein 24 | 76 | 201 | 0.4 |
| ASS1 | Argininosuccinate synthetase | 1642 | 4745 | 0.4 |
| HAL | Histidine ammonia-lyase | 13 | 70 | 0.4 |
| KDELC1 | KDEL (Lys-Asp-Glu-Leu) containing 1 | 130 | 314 | 0.4 |
| MAOA | Monoamine oxidase A | 11 | 33 | 0.5 |
| SULT1A1 | Sulfotransferase family, cytosolic, 1A, member 1 | 634 | 1452 | 0.5 |